Yes, you can use EndNote software on your Mac and ipad. A video can be found below which covers using EndNote desktop and EndNote online with a Mac. Other resources on how to use EndNote on your ipad can be found here.
EndNote is compatible with Apple's Pages software (watch this video for step-by-step help). However, the EndNote CWYW plugin is not currently compatible with Office 2016.
Please note that the EndNote Support Team is not able to support Mac users, although we will do our best to point you to useful information.
Papers software is an alternative to EndNote. See here for details.